Using Mamba to install Conda packages Mamba is an alternative to Conda package manager. The main advantage is its speed regarding dependency resolution. Setting up Mamba The proposed installation is based on micromamba and doesn't require any installation on the cluster. You just have to add the following line to your ~/.bashrc file: export MAMBA_ROOT_PREFIX="/work/FAC/INSTITUTE/PI/PROJECT/mamba_root" Of course, replace /work/FAC/INSTITUTE/PI/PROJECT with the path corresponding to your project. Then, you just have to load the module and run the initialization process with the following command: module load micromamba mamba_init Finally, you have to logout from the cluster and the environment will be properly configured at the next login. Using Mamba Instead of using conda commands, you can replace conda with micromamba . For instance: micromamba create --prefix ./my_mamba_env micromamba activate ./my_mamba_env micromamba install busco -c conda-forge -c bioconda busco -v micromamba deactivate Restriction You cannot use Mamba with virtual environment created previously with Conda. Such environments must be recreated.